HCID 178428478, compound → (E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

HRID 2236788Notes

Reaction equation

HRID 2236788 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\NC1C=NC(C2C[C@H](C)N[C@H](C)C2)=C(C)C=1.BrC1C=C2C(=CC=1)[C:38](=[O:42])NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/[O:42][CH3:38]

Participants

3

Reactant 2

HCID 178428478HCID 178428478, compoundHCID 178429948HCID 178429948, compound

Product 1

HCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 900 mg (86% yield) of solid is obtained from 630 mg (2.23 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 0.14 g (0.608 mmol) of 6-[(2R,6S)-2,6-dimethylpiperidin-4-yl]-5-methylpyridin-3-yl}amine; mp: 194-195° C.;

Sources & evidence

ORD record
ord-d8054dd89c9f4e22a4d5d8273ea31051
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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