HCID 178428478, compound → (E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

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Reaction Steps

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 900 mg (86% yield) of solid is obtained from 630 mg (2.23 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 0.14 g (0.608 mmol) of 6-[(2R,6S)-2,6-dimethylpiperidin-4-yl]-5-methylpyridin-3-yl}amine; mp: 194-195° C.;

Provenance & Evidence