反应详情

A mixture of 2-aminomethyl-5-propoxy-pyridin-4-ol (137 mg, 0.75 mmole) in 10 mL of N,N-dimethylformamide is stirred, then 4-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione (247 mg, 0.75 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is evaporated to dryness, triturated with 5% methanol in chlororform, filtered washed with fresh 5% methanol in chloroform, washed with acetonitrile and dried to give a pink solid, 313 mg, (87%); MS (ES+): m/z 479.9 (M+H).

1. stirringthe reaction mixture stirred for one hour
2. customThe reaction mixture is evaporated to dryness
3. customtriturated with 5% methanol in chlororform
4. filtrationfiltered
5. washwashed with fresh 5% methanol in chloroform
6. washwashed with acetonitrile
7. customdried
8. customto give a pink solid, 313 mg, (87%)