HCID 178429948, compound → HCID 59205050, compound

HRID 2236815Notes

Reaction equation

HRID 2236815 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[NH:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:27][CH2:26][CH:25]([N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[CH2:24][CH2:23]2)=[C:18]([F:33])[CH:17]=1.BrC1C=C2C(=CC=1)[C:41](=[O:45])NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/[O:45][CH3:41].[F:33][C:18]1[CH:17]=[C:16]([NH2:15])[CH:21]=[CH:20][C:19]=1[N:22]1[CH2:27][CH2:26][CH:25]([N:28]2[CH2:29][CH2:30][CH2:31][CH2:32]2)[CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178518263HCID 178518263, compound

Product 2

HCID 59205050HCID 59205050, compoundHCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.18 g (40.0% yield) of brown solid is obtained from 0.25 g (0.89 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 0.25 g (1.07 mmol) of [3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]amine: mp 204-205° C.; MS (ESI) m/z 513.0 (M+H)+1

Sources & evidence

ORD record
ord-7296da49d8644844a80a9e1942c01571
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

Loading…