HCID 178429948, compound → HCID 59205050, compound

Participants

Reaction Steps

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.18 g (40.0% yield) of brown solid is obtained from 0.25 g (0.89 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 0.25 g (1.07 mmol) of [3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]amine: mp 204-205° C.; MS (ESI) m/z 513.0 (M+H)+1

Provenance & Evidence