反应详情

A mixture of 2-n-pentylpropane-1,3diol (8 g, 0.054 m), 4-carboxybenzaldehyde (8 g, 0.053 m), benzene (200 ml) and a catalytic amount of 4-toluenesulfonic acid was azeotropically refluxed until no more water was collected. The cold reaction mixture was washed with saturated NaHCO3 solution and water and then dried over anhydrous sodium sulfate. The solvent was evaporated and the residue was crystallized from ethanol to yield 4-(5-n-pentyl-1,3-dioxan-2-yl) benzoic acid (12 g, 80%)

1. customwas collected
2. customThe cold reaction mixture
3. washwas washed with saturated NaHCO3 solution and water
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was evaporated
6. customthe residue was crystallized from ethanol