Hydrochloric Acid → HCID 68699969, compound

Participants

Reaction Steps

To a sample of tert-butyl {4-[4-({[2-(dimethylamino)ethyl]amino}methyl)piperidin-1-yl]phenyl}carbamate (approximately 1.0 mmol) is added hydrogen chloride solution (4 N in dioxane (10 mL). After stirring overnight at room temperature, the solvent is evaporated under reduced pressure. The solid material is collected, washed with diethyl ether, and dried under house vacuum to give the intermediate N-[1-(4-amino-phenyl)-piperidin-4-ylmethyl]-N′,N′-dimethyl-ethane-1,2-diamine tetrahydrochloride (0.29 g, 69%), which is used in the following step without further purification.

Provenance & Evidence