Hydrochloric Acid → HCID 68699969, compound

HRID 2236842Notes

Reaction equation

HRID 2236842 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][NH:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(=O)OC(C)(C)C)=[CH:15][CH:14]=2)[CH2:9][CH2:8]1.[ClH:28]>O1CCOCC1>[ClH:28].[ClH:28].[ClH:28].[ClH:28].[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([N:10]2[CH2:9][CH2:8][CH:7]([CH2:6][NH:5][CH2:4][CH2:3][N:2]([CH3:27])[CH3:1])[CH2:12][CH2:11]2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86619597HCID 86619597, compound

Product 1

HCID 68699969HCID 68699969, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a sample of tert-butyl {4-[4-({[2-(dimethylamino)ethyl]amino}methyl)piperidin-1-yl]phenyl}carbamate (approximately 1.0 mmol) is added hydrogen chloride solution (4 N in dioxane (10 mL). After stirring overnight at room temperature, the solvent is evaporated under reduced pressure. The solid material is collected, washed with diethyl ether, and dried under house vacuum to give the intermediate N-[1-(4-amino-phenyl)-piperidin-4-ylmethyl]-N′,N′-dimethyl-ethane-1,2-diamine tetrahydrochloride (0.29 g, 69%), which is used in the following step without further purification.

Workup

  1. customthe solvent is evaporated under reduced pressure
  2. customThe solid material is collected
  3. washwashed with diethyl ether
  4. customdried under house vacuum

Sources & evidence

ORD record
ord-95c8ec0cbe8e478d89bbc875df1c2e1a
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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