HCID 23143856, compound → HCID 178518360, compound

HRID 2236862Notes

Reaction equation

HRID 2236862 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([OH:15])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1.[I:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23](=[O:27])[NH:22][C:21](=[O:28])[C:20]2=[CH:29]OC>CN(C)C=O>[OH:15][C:5]1[CH:4]=[C:3]([CH2:2][NH:1][CH:29]=[C:20]2[C:19]3[C:24](=[CH:25][CH:26]=[C:17]([I:16])[CH:18]=3)[C:23](=[O:27])[NH:22][C:21]2=[O:28])[CH:8]=[CH:7][C:6]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 23143856HCID 23143856, compoundHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione

Product 1

HCID 178518360HCID 178518360, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Aminomethyl-biphenyl-2-ol (80 mg, 0.4 mmol) and 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (110 mg, 0.34 mmol) is stirred in N,N-dimethylformamide (5 mL). After which N,N-dimethylformamide is removed under vacuum and the residue is triturated with MeOH. The precipitate thus formed is collected and washed with MeOH and dried to provide the title compound (151 mg, 89%). MS (ESI): 495.1 (M−1)−1.

Workup

  1. customAfter which N,N-dimethylformamide is removed under vacuum
  2. customthe residue is triturated with MeOH
  3. customThe precipitate thus formed
  4. customis collected
  5. washwashed with MeOH
  6. customdried

Sources & evidence

ORD record
ord-dae6d350212d43ed91dae3eabd769649
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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