反应详情

4-Aminomethyl-biphenyl-2-ol (80 mg, 0.4 mmol) and 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (110 mg, 0.34 mmol) is stirred in N,N-dimethylformamide (5 mL). After which N,N-dimethylformamide is removed under vacuum and the residue is triturated with MeOH. The precipitate thus formed is collected and washed with MeOH and dried to provide the title compound (151 mg, 89%). MS (ESI): 495.1 (M−1)−1.

1. customAfter which N,N-dimethylformamide is removed under vacuum
2. customthe residue is triturated with MeOH
3. customThe precipitate thus formed
4. customis collected
5. washwashed with MeOH
6. customdried