HCID 59300285, compound → HCID 178440917, compound

HRID 2236864Notes

Reaction equation

HRID 2236864 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1[C:24]1C=C[CH:27]=[CH:26][CH:25]=1.IC1C=C2C(=CC=1)C(=O)NC(=O)C2=COC.NCC1C=CC(CCCC)=C(O)C=1>>[CH2:24]([C:3]1[CH:4]=[CH:5][C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])=[CH:7][C:2]=1[OH:1])[CH2:25][CH2:26][CH3:27]

Participants

4

Reactant 3

HCID 59300285HCID 59300285, compoundHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178440917HCID 178440917, compoundYield 65%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (85 mg, 0.26 mmol) and 5-Aminomethyl-2-butyl-phenol (54 mg, 0.3 mmol) in 65% yield: MS (ESI): 475.2 (M−1)−1.

Sources & evidence

ORD record
ord-0f895321f63846e8aeae3868fb82d545
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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