3-(Aminomethyl)-4-iodophenol → HCID 178518375, compound

HRID 2236865Notes

Reaction equation

HRID 2236865 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1C1C=CC=CC=1.[I:30]C1C=C2C(=CC=1)C(=O)NC(=O)C2=COC.NCC1C=C(O)C=CC=1I>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([I:30])=[C:6]([CH:7]=1)[CH2:8][NH:9][CH:10]=[C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[C:14](=[O:22])[NH:13][C:12]1=[O:23]

Participants

4

Reactant 3

HCID 593000293-(Aminomethyl)-4-iodophenolHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178518375HCID 178518375, compoundYield 73%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (100 mg, 0.30 mmol) and 3-Aminomethyl-4-iodo-phenol (80 mg, 0.32 mmol) in 73% yield: MS (ESI): 545.0 (M−1)−1.

Sources & evidence

ORD record
ord-8261fbc0ac9a4c42ac200b7d8a7c4b4f
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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