4-Aminomethyl-4'-fluoro-biphenyl-2-ol → HCID 178518362, compound

HRID 2236868Notes

Reaction equation

HRID 2236868 reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])[C:5]2=[CH:14]OC.[NH2:17][CH2:18][C:19]1[CH:20]=[C:21]([OH:32])[C:22]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)=[CH:23][CH:24]=1>>[F:31][C:28]1[CH:27]=[CH:26][C:25]([C:22]2[CH:23]=[CH:24][C:19]([CH2:18][NH:17][CH:14]=[C:5]3[C:4]4[C:9](=[CH:10][CH:11]=[C:2]([I:1])[CH:3]=4)[C:8](=[O:12])[NH:7][C:6]3=[O:13])=[CH:20][C:21]=2[OH:32])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 592999224-Aminomethyl-4'-fluoro-biphenyl-2-olHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione

Product 1

HCID 178518362HCID 178518362, compoundYield 60%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione-2, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (90 mg, 0.27 mmol) and 4-Aminomethyl-4′-fluoro-biphenyl-2-ol (66 mg, 0.3 mmol) in 60% yield: MS (ESI): 513.1 (M−1)−1.

Sources & evidence

ORD record
ord-9a97f3278ed3462c9f33c07efe21df43
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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