反应详情

A mixture of 2-aminomethyl-5-propoxy-pyridin-4-ol (73 mg, 0.40 mmole), 5 mL of N,N-dimethylformamide is stirred, then 4-methoxymethylene-6-(furan-2-yl)-4H-isoquinoline-1,3-dione (108 mg, 0.40 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is evaporated to dryness, triturated with 5% methanol in chlororform, filtered washed with fresh 5% methanol in chloroform, washed with acetonitrile and dried to give a pale yellow solid, 139 mg, (83%); m.p. 288-90° C. dec; MS (ES+): m/z 420.2 (M+H).

1. stirringthe reaction mixture stirred for one hour
2. customThe reaction mixture is evaporated to dryness
3. customtriturated with 5% methanol in chlororform
4. filtrationfiltered
5. washwashed with fresh 5% methanol in chloroform
6. washwashed with acetonitrile
7. customdried
8. customto give a pale yellow solid, 139 mg, (83%)