3-(Aminomethyl)-4-iodophenol → HCID 178518301, compound

HRID 2236871Notes

Reaction equation

HRID 2236871 reaction equation
OC1C=C(CNC=C2C3C(=CC=C(I)C=3)C(=O)NC2=O)C=CC=1C1C=CC=CC=1.[O:30]1[CH:34]=[CH:33][CH:32]=[C:31]1[C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][CH:44]=1)[C:41](=[O:45])[NH:40][C:39](=[O:46])[C:38]2=[CH:47]OC.[NH2:50][CH2:51][C:52]1[CH:53]=[C:54]([OH:59])[CH:55]=[CH:56][C:57]=1[I:58]>>[O:30]1[CH:34]=[CH:33][CH:32]=[C:31]1[C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][CH:44]=1)[C:41](=[O:45])[NH:40][C:39](=[O:46])[C:38]2=[CH:47][NH:50][CH2:51][C:52]1[CH:53]=[C:54]([OH:59])[CH:55]=[CH:56][C:57]=1[I:58]

Participants

4

Reactant 3

HCID 593000293-(Aminomethyl)-4-iodophenolHCID 686963676-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178518301HCID 178518301, compoundYield 77%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dione (400 mg, 1.5 mmol) and 3-Aminomethyl-4-iodo-phenol (400 mg, 1.61 mmol) in 77% yield: MS (ESI): 485.1 (M−1)−1.

Sources & evidence

ORD record
ord-d1eb088139784bf8ad44c362d753e8ac
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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