5-(Aminomethyl)-2-iodophenol → HCID 178518367, compound

HRID 2236872Notes

Reaction equation

HRID 2236872 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1C1C=CC=CC=1.O1C=CC=C1C1C=C2C(=CC=1)C(=O)NC(=O)C2=COC.NCC1C=CC([I:59])=C(O)C=1>>[OH:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[I:59])[CH2:8][NH:9][CH:10]=[C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[C:14](=[O:22])[NH:13][C:12]1=[O:23]

Participants

4

Reactant 3

HCID 426255945-(Aminomethyl)-2-iodophenolHCID 686963676-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178518367HCID 178518367, compoundYield 80%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dione (60 mg, 0.22 mmol) and 5-Aminomethyl-2-iodo-phenol (58 mg, 0.23 mmol) in 80% yield: MS (ESI): 485.1 (M−1)−1.

Sources & evidence

ORD record
ord-f521638052f14abe8dc2db0a18f03fb2
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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