6-Iodoisoquinoline-1,3(2h,4h)-dione → HCID 178518366, compound

HRID 2236874Notes

Reaction equation

HRID 2236874 reaction equation
IC1C=C2C(=CC=1)C(=O)NC(=O)C2.[I:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[C:21](=[O:25])[NH:20][C:19](=[O:26])[C:18]2=[CH:27]OC.[NH2:30][CH2:31][C:32]1[CH:33]=[CH:34][C:35]([C:39]2[CH:43]=[CH:42][O:41][CH:40]=2)=[C:36]([OH:38])[CH:37]=1>>[O:41]1[CH:42]=[CH:43][C:39]([C:35]2[CH:34]=[CH:33][C:32]([CH2:31][NH:30][CH:27]=[C:18]3[C:17]4[C:22](=[CH:23][CH:24]=[C:15]([I:14])[CH:16]=4)[C:21](=[O:25])[NH:20][C:19]3=[O:26])=[CH:37][C:36]=2[OH:38])=[CH:40]1

Participants

4

Reactant 3

HCID 112661716-Iodoisoquinoline-1,3(2h,4h)-dioneHCID 426256705-Aminomethyl-2-furan-3-yl-phenolHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione

Product 1

HCID 178518366HCID 178518366, compoundYield 56%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4. -ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (85 mg, 0.26 mmol) and 5-Aminomethyl-2-furan-3-yl-phenol in 56% yield: MS (ESI): 487.1 (M+1)+1.

Sources & evidence

ORD record
ord-07526fc657f7496fb6ef6a719152db94
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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