HCID 59299973, compound → HCID 178483196, compound

HRID 2236884Notes

Reaction equation

HRID 2236884 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.IC1C=C2C(=CC=1)C(=O)NC(=O)C2=COC.NCC1C=C(O)C(C2C=CC=C([CH2:60][N:61]([CH3:63])[CH3:62])C=2)=CC=1>>[CH3:60][N:61]([CH2:63][C:26]1[CH:25]=[C:24]([C:3]2[CH:4]=[CH:5][C:6]([CH2:8][NH:9][CH:10]=[C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=4)[C:14](=[O:22])[NH:13][C:12]3=[O:23])=[CH:7][C:2]=2[OH:1])[CH:29]=[CH:28][CH:27]=1)[CH3:62]

Participants

4

Reactant 3

HCID 59299973HCID 59299973, compoundHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178483196HCID 178483196, compoundYield 24%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound (purified through chromatography) is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (50 mg, 0.15 mmol) and 4-aminomethyl-3′-dimethylaminomethyl-biphenyl-2-ol (50 mg, 0.18 mmol) in 24% yield: MS (ESI): 554.0 (M+1)+1.

Sources & evidence

ORD record
ord-0ce6be3025624900b36ce21df7555b67
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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