反应详情

An amount of 40.0 mg (0.154 mmol) of (4E)-6-t-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (based on a sample that is 39% pure by weight), is dissolved in N,N-dimethylformamide (3 mL), followed by the addition of 31 mg (0.154 mmol) of 2-aminomethyl-5-phenyl-pyridin-4-ol. All solids dissolved and after the mixture is stirred at room temperature for 2 hours, the solution is evaporated to dryness in vacuo, treated with acetonitrile, filtered and washed several times with fresh acetonitrile and dried to give 44 mg of the title compound as a pink solid (66% yield); mp 195-218° C. dec, MS data ES(+) 428.4 m/e.

1. dissolutionAll solids dissolved
2. customthe solution is evaporated to dryness in vacuo
3. additiontreated with acetonitrile
4. filtrationfiltered
5. washwashed several times with fresh acetonitrile
6. customdried