HCID 59300092, compound → HCID 178440614, compound

HRID 2236899Notes

Reaction equation

HRID 2236899 reaction equation
OC1C=C(CNC=C2C3C(=CC=C(I)C=3)C(=O)NC2=O)C=CC=1C1C=CC=CC=1.[C:30]([C:34]1[CH:35]=[C:36]2[C:41](=[CH:42][CH:43]=1)[C:40](=[O:44])[NH:39][C:38](=[O:45])[C:37]2=[CH:46]OC)([CH3:33])([CH3:32])[CH3:31].[NH2:49][CH2:50][C:51]1[C:52]([F:63])=[CH:53][C:54]([C:58]2[CH:62]=[CH:61][O:60][CH:59]=2)=[C:55]([OH:57])[CH:56]=1>>[C:30]([C:34]1[CH:35]=[C:36]2[C:41](=[CH:42][CH:43]=1)[C:40](=[O:44])[NH:39][C:38](=[O:45])[C:37]2=[CH:46][NH:49][CH2:50][C:51]1[CH:56]=[C:55]([OH:57])[C:54]([C:58]2[CH:62]=[CH:61][O:60][CH:59]=2)=[CH:53][C:52]=1[F:63])([CH3:33])([CH3:32])[CH3:31]

Participants

4

Reactant 3

HCID 59300092HCID 59300092, compoundHCID 686925676-tert-Butyl-4-methoxymethylene-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178440614HCID 178440614, compoundYield 60%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-tert-Butyl-4-methoxymethylene-4H-isoquinoline-1,3-dione (11 mg, 0.042 mmol) and 5-Aminomethyl-4-fluoro-2-furan-3-yl-phenol (12 mg, 0.058 mmol) in 60% yield: MS (ESI): 433.2 (M−1)−1.

Sources & evidence

ORD record
ord-320bce8c841c494d8755f02f31dd3dc1
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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