tert-Butoxy bis(dimethylamino)methane → HCID 86619604, compound

HRID 2236908Notes

Reaction equation

HRID 2236908 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)[C:4](=[O:13])[CH:3]=1.C(O[CH:19](N(C)C)[N:20]([CH3:22])[CH3:21])(C)(C)C>CN(C)C=O>[CH3:19][N:20]([CH3:22])[CH:21]=[CH:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)[C:4](=[O:13])[CH:3]=1

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 68699101HCID 68699101, compound

Product 1

HCID 86619604HCID 86619604, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-methyl-1-(3-thienyl)pyridin-2(1H)-one (0.73 g, 3.8 mmol), tert-butoxybis(dimethylamino)methane (3 mL, 15 mmol), and N,N-dimethylformamide (4 mL) is heated in a 100° C. oil bath for 3 hours and then concentrated to dryness under reduced pressure. A quantitative yield of 4-(2-dimethylamino-vinyl)-1-thiophen-3-yl-1H-pyridin-2-one is assumed, and the material is carried on without further purification.

Workup

  1. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-a4e15498e29c44a7a5884ed8199da8f8
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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