Bis(2-chloroethyl)amine hydrochloride → HCID 178479654, compound

HRID 2236922Notes

Reaction equation

HRID 2236922 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:9]=[C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13](=[O:20])[NH:12][C:11]2=[O:21])=[CH:4][CH:3]=1.Cl.[Cl:23][CH2:24][CH2:25][NH:26][CH2:27][CH2:28]Cl>>[ClH:23].[N:1]1([C:2]2[CH:7]=[CH:6][C:5]([NH:8][CH:9]=[C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[C:13](=[O:20])[NH:12][C:11]3=[O:21])=[CH:4][CH:3]=2)[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 522769Bis(2-chloroethyl)amine hydrochlorideHCID 178507738HCID 178507738, compound

Product 1

HCID 178479654HCID 178479654, compoundYield 99.8%

Procedure

A dry mixture of 4-[(4-Amino-phenylamino)-methylene]-4H-isoquinoline-1,3-dione (140 mg, 0.5 mmol) and bis(chloroethyl)amine hydrochloride (90 mg, 0.5 mmol) is placed in a microwave at 900 W for 10 minutes. The crude product, 4-[(4-piperazin-1-yl-phenylamino)-methylene]-4H-isoquinoline-1,3-dione hydrochloride (192 mg), thus obtained is used as such for the next reaction.

Sources & evidence

ORD record
ord-75ab56ab3fd545629b888a8f8cfc3aca
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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