HCID 86761111, compound → HCID 86761110, compound

HRID 2236958Notes

Reaction equation

HRID 2236958 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)[CH2:3]1.[C:17]([OH:23])([C:19]([F:22])([F:21])[F:20])=[O:18]>C(O)C.[Pd]>[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:3]1.[C:17]([OH:23])([C:19]([F:22])([F:21])[F:20])=[O:18]

Participants

4

Reactant 1

HCID 86761111HCID 86761111, compound

Product 1

HCID 86761110HCID 86761110, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-methyl-3-(4-nitro-phenoxy)-pyrrolidine•TFA (0.34 g, 1.0 mmol) in ethanol (10 mL) is hydrogenated for one hour at atmospheric pressure over 10% Pd/C. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to give 4-(1-methyl-pyrrolidin-3-yloxy)-phenylamine•TFA as a black solid.

Workup

  1. filtrationThe mixture is filtered through a pad of diatomaceous earth
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-02dd44c282304d9596e67cdbff5d597a
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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