Sodium Carbonate → HCID 20520584, compound

HRID 223712Notes

Reaction equation

HRID 223712 reaction equation
Br[CH:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[CH2:3][C:4]([O-:6])=[O:5].[C:15]([O:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH2:28])=[S:27])=[CH:24][CH:23]=1)(=[O:20])[CH2:16][CH2:17][CH2:18][CH3:19].C(=O)([O-])[O-:32].[Na+].[Na+]>C(O)(C)C>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2([OH:32])[CH:2]([CH2:3][C:4]([OH:6])=[O:5])[S:27][C:26]([C:25]3[CH:24]=[CH:23][C:22]([O:21][C:15](=[O:20])[CH2:16][CH2:17][CH2:18][CH3:19])=[CH:30][CH:29]=3)=[N:28]2)=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 54369734HCID 54369734, compoundHCID 86738610HCID 86738610, compound

Product 1

HCID 20520584HCID 20520584, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-Bromo-3-(4-chlorobenzyl)propionate acid and an equimolar amount of 4-valeryloxythio-benzamide are stirred in isopropyl alcohol solvent containing sodium carbonate to give 4-(4-chlorophenyl)-4-hydroxy-2-(4-valeryloxyphenyl)-2-thiazolin-5-acetic acid. This compound is dehydrated by heating to give the title compound.

Sources & evidence

ORD record
ord-15db5331696d4a0e8d815be2a96424c3
Source dataset
uspto-grants-1982_10
Patent number
US04356185

Reaction notes

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