Hydrochloric Acid → HCID 131727209, compound

HRID 2237191Notes

Reaction equation

HRID 2237191 reaction equation
[ClH:1].O1CCOCC1.[CH2:8]([NH:15][C:16]1[CH:21]=[C:20]([O:22][C:23]2[CH:28]=[CH:27][C:26]([NH:29]C(=O)OC(C)(C)C)=[CH:25][C:24]=2[F:37])[CH:19]=[CH:18][N:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[ClH:1].[NH2:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:20]2[CH:19]=[CH:18][N:17]=[C:16]([NH:15][CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:21]=2)=[C:24]([F:37])[CH:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59852895HCID 59852895, compound

Product 1

HCID 131727209HCID 131727209, compoundYield 100%

Procedure

Anhydrous HCl in dioxane (4N, 2.00 mL, 8.00 mmol, 165 eq) was added to tert-butyl 4-(2-(benzylamino)pyridin-4-yloxy)-3-fluorophenylcarbamate (0.020 g, 0.0489 mmol, 1.0 eq) and the reaction mixture was stirred at room temperature for 12 h. The reaction mixture was concentrated in vacuo to afford the title compound (0.017 g, 100%) a solid that was used without further purification. MS(ESI+) m/z 310 (M+H)+; HRMS (ESI+) calcd.: 310.1356, found: 310.1364.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-037e5ab0d7194b819c8b5ab81dc090c5
Source dataset
uspto-grants-2010_05
Patent number
US07714138B2

Reaction notes

Loading…