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HRID2237376

反应详情

EQUATION

反应方程式

HRID 2237376 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)Cl
HCID6397

Chlorotrimethylsilane

C3H9ClSi

结构：CC(C)(C)OC(=O)N[C@@H](C[Si](C)(C)C)C(=O)O
HCID57435232

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H](N)C[Si](C)(C)C.Cl
HCID86619132

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

The compound from example 72A (300 mg) is dissolved in methanol (3 ml) and cooled to 0° C. Trimethylsilyl chloride (590 mg, 4.7 equivalents) is added dropwise within 30 min and the mixture is warmed to RT overnight. The volatile components are removed on a Rotavapor and subsequently under high vacuum. The target compound is obtained (224 mg, 92% of theory).

WORKUP

后处理

  1. temperaturethe mixture is warmed to RT overnight
  2. customThe volatile components are removed on a Rotavapor and subsequently under high vacuum
  3. customThe target compound is obtained (224 mg, 92% of theory)