Chlorotrimethylsilane → 3-Trimethylsilyl-L-alanine methyl ester hydrochloride

Participants

Reaction Conditions

Reaction Steps

The compound from example 72A (300 mg) is dissolved in methanol (3 ml) and cooled to 0° C. Trimethylsilyl chloride (590 mg, 4.7 equivalents) is added dropwise within 30 min and the mixture is warmed to RT overnight. The volatile components are removed on a Rotavapor and subsequently under high vacuum. The target compound is obtained (224 mg, 92% of theory).

Provenance & Evidence