Trifluoroacetic acid methylene chloride → HCID 86619130, compound

HRID 2237378Notes

Reaction equation

HRID 2237378 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C@H:4]([CH2:13][C:14]([CH3:17])([CH3:16])[CH3:15])[NH:5]C(OC(C)(C)C)=O.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20].ClCCl>>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[CH3:1][O:2][C:3](=[O:18])[C@H:4]([CH2:13][C:14]([CH3:16])([CH3:15])[CH3:17])[NH2:5]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 86619131HCID 86619131, compound

Product 1

HCID 86619130HCID 86619130, compound

Procedure

The (2S)—N-tert-butoxycarbonyl-3-tert-butyl-L-alanine methyl ester (529 mg, 2.04 mmol) is stirred at RT in TFA/dichloromethane 1:3 (3 ml), and the solution is concentrated on a rotary evaporator and dried under high vacuum. 540 mg (97% of theory) of product are obtained.

Workup

  1. concentrationthe solution is concentrated on a rotary evaporator
  2. customdried under high vacuum
  3. custom540 mg (97% of theory) of product are obtained

Sources & evidence

ORD record
ord-31d57d1a62364e709a624f6c6dd597a3
Source dataset
uspto-grants-2010_05
Patent number
US07718611B2

Reaction notes

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