Hydrochloric Acid → HCID 86619133, compound

HRID 2237381Notes

Reaction equation

HRID 2237381 reaction equation
C(OC([NH:8][C@@H:9]([C:15]([NH:17][C@H:18]([C:24]([OH:26])=[O:25])[CH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:16])[CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[C:11]([CH2:10][C@H:9]([C:15]([NH:17][C@H:18]([C:24]([OH:26])=[O:25])[CH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:16])[NH2:8])([CH3:14])([CH3:12])[CH3:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59709821HCID 59709821, compound

Product 1

HCID 86619133HCID 86619133, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

N-(tert-Butoxycarbonyl)-3-tert-butyl-D-alanyl-3-tert-butyl-L-alanine (4.5 g, 12.1 mmol, example 10A) is predissolved in dioxane (3 ml). At RT, a 4 N solution of hydrogen chloride in dioxane (30.2 mmol, 120 mmol, 10 equivalents) is added dropwise. The reaction mixture is stirred for 30 min, evaporated in vacuo and dried under high vacuum. The title compound is obtained as a solid (3.5 g, 99% of theory).

Workup

  1. customevaporated in vacuo
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-a9446e0257694a89958ffb15b681f0b7
Source dataset
uspto-grants-2010_05
Patent number
US07718611B2

Reaction notes

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