反应详情

温度

60 °C

A mixture of 5-bromo-1,2,3,4-tetrahydro-2-methylisoquinolin-8-amine (IV, 3.25 g, 13.5 mmol), chloral hydrate (2.3 g), hydroxylamine hydrochloride (2.9 g), 12 g Na2SO4 (12 g) in H2O:EtOH (3:1, 50 mL) was refluxed for 1 hr whereafter it was cooled to 60° C. and carefully basified with 4N NaOH to pH=7 and allowed to cool. The solid was collected by filtration, washed with water and dried under vacuum to give V.

1. temperaturewas refluxed for 1 hr whereafter it
2. temperatureto cool
3. filtrationThe solid was collected by filtration
4. washwashed with water
5. customdried under vacuum
6. customto give V