HRID2237400

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3696

Imipramine

C19H24N2

3 次

结构：O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O

HCID8546

Pamoic acid

C23H16O6

2 次

结构：O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O.[Na+]

HCID10179807

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCCN1c2ccccc2CCc2ccccc21.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O

HCID16052002

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The pamoate salt of Imipramine can be prepared by treatment of Imipramine with pamoic salt or pamoic acid in a solvent or solvent mix. Imipramine pamoate was prepared by adding a solution of imipramine in an appropriate solvent, e.g. acidic water, to a solution of disodium pamoate, pamoic acid or other pamoate salt and stirred resulting in precipitation of the salt.

WORKUP

后处理

additionmix
customresulting in precipitation of the salt

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c01f26a100e645d6b8259bc50ec03d4a
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07718649B1
来源说明: uspto-grants-2010_05

反应 SMILES

[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][N:7]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[CH2:15][CH2:14][C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)[CH3:3].[CH:22]1[CH:23]=[CH:24][C:25]2[C:26](=[CH:28][C:29]([C:48]([OH:50])=[O:49])=[C:30]([OH:47])[C:31]=2[CH2:32][C:33]2[C:42]([OH:43])=[C:41]([C:44]([OH:46])=[O:45])[CH:40]=[C:39]3[C:34]=2[CH:35]=[CH:36][CH:37]=[CH:38]3)[CH:27]=1.C1C=C2C=C(C(O)=O)C(O)=C(CC3C4C(=CC=CC=4)C=C(C(O)=O)C=3O)C2=CC=1.[Na+]>O>[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][N:7]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=2[CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]1=2)[CH3:3].[CH:22]1[CH:23]=[CH:24][C:25]2[C:26](=[CH:28][C:29]([C:48]([OH:50])=[O:49])=[C:30]([OH:47])[C:31]=2[CH2:32][C:33]2[C:42]([OH:43])=[C:41]([C:44]([OH:46])=[O:45])[CH:40]=[C:39]3[C:34]=2[CH:35]=[CH:36][CH:37]=[CH:38]3)[CH:27]=1