反应详情

The product of step c) (800 mg, 2.0 mmol) was dissolved in 150 mL EtOH and treated with 800 mg of 10% Pd/C (wet, Degussa grade E101). After stirring overnight, another 300 mg of Pd was added and stirring was continued 3 hours. The reaction was filtered through celite, diluted with DCM (300 mL), and washed with water (1×300 mL). The organic layer was dried over MgSO4 and concentrated to give 475 mg of the subtitle compound.

1. stirringstirring
2. waitwas continued 3 hours
3. filtrationThe reaction was filtered through celite
4. additiondiluted with DCM (300 mL)
5. washwashed with water (1×300 mL)
6. dry with materialThe organic layer was dried over MgSO4
7. concentrationconcentrated