2,3-Dibromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester → 4-Methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester

Participants

Reaction Steps

The product of step c) (800 mg, 2.0 mmol) was dissolved in 150 mL EtOH and treated with 800 mg of 10% Pd/C (wet, Degussa grade E101). After stirring overnight, another 300 mg of Pd was added and stirring was continued 3 hours. The reaction was filtered through celite, diluted with DCM (300 mL), and washed with water (1×300 mL). The organic layer was dried over MgSO4 and concentrated to give 475 mg of the subtitle compound.

Provenance & Evidence