Trimethylsilyl iodide → HCID 46849913, compound

HRID 2237450Notes

Reaction equation

HRID 2237450 reaction equation
C(OC([N:6]1[CH2:12][CH2:11][C:10]2[C:13]([Cl:20])=[C:14]([C:16]([F:19])([F:18])[F:17])[S:15][C:9]=2[CH2:8][CH2:7]1)=O)C.I[Si](C)(C)C>C(Cl)Cl>[Cl:20][C:13]1[C:10]2[CH2:11][CH2:12][NH:6][CH2:7][CH2:8][C:9]=2[S:15][C:14]=1[C:16]([F:18])([F:17])[F:19]

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 68469945HCID 68469945, compound

Product 1

HCID 46849913HCID 46849913, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product from step c) (14.4 mg, 0.044 mmol) in CH2Cl2 (220 μl) was treated with iodotrimethylsilane (19 μl, 0.13 mmol) at 60° C. for 12 hours. The reaction was quenched by the addition of MeOH and the solvent was evaporated. The residue was purified by preparative LC/MS providing 2.3 mg (18%) of the title compound. MS: ESI (positive): 256 (M+H).

Workup

  1. customThe reaction was quenched by the addition of MeOH
  2. customthe solvent was evaporated
  3. customThe residue was purified by preparative LC/MS

Sources & evidence

ORD record
ord-74ceac0c8d884f8ca31489c91491deb6
Source dataset
uspto-grants-2010_05
Patent number
US07718647B2

Reaction notes

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