Hydrochloric Acid → HCID 12786631, compound

HRID 223747Notes

Reaction equation

HRID 223747 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[C:6]([C:8]2[O:9]CC(C)(C)N=2)[CH:7]=1.Cl.[O:23]1CCOCC1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:4][CH:3]=1)[C:8]([OH:9])=[O:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 12786630HCID 12786630, compound

Product 1

HCID 12786631HCID 12786631, compound

Procedure

The starting material is prepared as follows: The mixture of 17 g of 2-(5-chloro-2-o-tolylphenyl)-4,4-dimethyl-2-oxazoline (prepared as shown in Example 2), 150 ml of p-dioxane, and 160 ml of 5 N aqueous hydrochloric acid is refluxed for 3 days while stirring. It is evaporated, the residue taken up in diethyl ether, the organic phase separated, dried, evaporated and the residue crystallized from hexane to yield the 3-chloro-6-o-tolylbenzoic acid melting at 135°-137°.

Workup

  1. customThe starting material is prepared
  2. temperatureis refluxed for 3 days
  3. customIt is evaporated
  4. customthe organic phase separated
  5. customdried
  6. customevaporated
  7. customthe residue crystallized from hexane

Sources & evidence

ORD record
ord-3c2cc0bdd6b54e2fa17c8b835c75e502
Source dataset
uspto-grants-1982_10
Patent number
US04356176

Reaction notes

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