HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 3-(3-chloropropyl)-1-(3-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide | HCID 68584013 | — |
| Product | N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride | HCID 68583132 | — |
Reaction Steps
In an analogous manner to Example 1, step 8, 3-(3-chloropropyl)-1-(3-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (21 mg) was reacted with methylamine and then treated with HCl to provide N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride (18 mg):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718652B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-a8d3699cf29842e495f5b09c66a19ff2 |
| Source note | uspto-grants-2010_05 |