Hydrochloric Acid → N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride

HRID 2237472Notes

Reaction equation

HRID 2237472 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[S:6]1(=[O:23])=[O:22].[CH3:24][NH2:25].Cl>>[ClH:1].[CH3:24][NH:25][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[S:6]1(=[O:23])=[O:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 685840133-(3-chloropropyl)-1-(3-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

Product 1

HCID 68583132N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride

Procedure

In an analogous manner to Example 1, step 8, 3-(3-chloropropyl)-1-(3-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (21 mg) was reacted with methylamine and then treated with HCl to provide N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride (18 mg):

Sources & evidence

ORD record
ord-a8d3699cf29842e495f5b09c66a19ff2
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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