(4-Methoxyphenyl)boronic acid → HCID 68581909, compound

HRID 2237483Notes

Reaction equation

HRID 2237483 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][S:6]1(=[O:16])=[O:15].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:22]2[CH:23]=[CH:24][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)[S:6]1(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 442494893-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

Product 1

HCID 68581909HCID 68581909, compound

Procedure

In an analogous manner to Example 1 step 7, 3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (456 mg) was coupled to p-methoxyphenylboronic acid to provide 3-(3-chloropropyl)-1-(4-methoxyphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (132 mg):

Sources & evidence

ORD record
ord-4c1043ab355b4e44b4678820fee5a7ea
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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