4-Bromobutanol → 3-(4-bromobutyl)-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[CH2:11][NH:10][S:9]1(=[O:19])=[O:18].[Br:20][CH2:21][CH2:22][CH2:23][CH2:24]O>>[Br:20][CH2:21][CH2:22][CH2:23][CH2:24][N:10]1[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[S:9]1(=[O:19])=[O:18]Participants
3
Procedure
In an analogous manner to Example 11 step 4, a solution of 1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.75 g, 2.7 mmol) was reacted with 4-bromobutanol (0.83 mL, 5.2 mmol) to afford 3-(4-bromobutyl)-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.74 g, 66%) as a white solid:
Sources & evidence
- ORD record
- ord-1f59b262b9bd4b658f0bc77626a2bdd3
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07718652B2
Reaction notes
Loading…