HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobutanol → 3-(4-bromobutyl)-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobutanol | HCID 118388 | — |
| Reactant | 1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide | HCID 68581171 | — |
| Product | 3-(4-bromobutyl)-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide | HCID 68582114 | 66.3% |
Reaction Steps
In an analogous manner to Example 11 step 4, a solution of 1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.75 g, 2.7 mmol) was reacted with 4-bromobutanol (0.83 mL, 5.2 mmol) to afford 3-(4-bromobutyl)-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.74 g, 66%) as a white solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718652B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-1f59b262b9bd4b658f0bc77626a2bdd3 |
| Source note | uspto-grants-2010_05 |