Hydrochloric Acid → HCID 57421206, compound

Participants

Reaction Steps

1.69 g of (R)-2-methoxy-2-methyl-3-phenyl-propionic acid methyl ester are dissolved in 40 ml of methanol. 40 ml of a 1M aqueous lithium hydroxide solution are added and the mixture is stirred for 2.5 hours at room temperature. The reaction mixture is neutralised with 1M HCl and concentrated by evaporation. The residue is purified by flash chromatography (SiO2 60F) to provide the title compound as a yellow oil. Rf=0.70 (35:13:5 dichloromethane-methanol-acetic acid).

Provenance & Evidence