Hydrochloric Acid → HCID 57421206, compound

HRID 2237745Notes

Reaction equation

HRID 2237745 reaction equation
C[O:2][C:3](=[O:15])[C@@:4]([O:13][CH3:14])([CH3:12])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[Li+].Cl>CO>[CH3:14][O:13][C@:4]([CH3:12])([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:15])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 57421207HCID 57421207, compound

Product 1

HCID 57421206HCID 57421206, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.69 g of (R)-2-methoxy-2-methyl-3-phenyl-propionic acid methyl ester are dissolved in 40 ml of methanol. 40 ml of a 1M aqueous lithium hydroxide solution are added and the mixture is stirred for 2.5 hours at room temperature. The reaction mixture is neutralised with 1M HCl and concentrated by evaporation. The residue is purified by flash chromatography (SiO2 60F) to provide the title compound as a yellow oil. Rf=0.70 (35:13:5 dichloromethane-methanol-acetic acid).

Workup

  1. concentrationconcentrated by evaporation
  2. customThe residue is purified by flash chromatography (SiO2 60F)

Sources & evidence

ORD record
ord-00e4f9fde3e84e8bb1e33098801167a8
Source dataset
uspto-grants-2010_05
Patent number
US07718675B2

Reaction notes

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