Hydrochloric Acid → HCID 57421209, compound

HRID 2237747Notes

Reaction equation

HRID 2237747 reaction equation
C([O:3][C:4](=[O:13])[C:5]([N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1)([CH3:7])[CH3:6])C.[OH-].[Na+].Cl>CO>[N:8]1([C:5]([CH3:7])([CH3:6])[C:4]([OH:13])=[O:3])[CH:12]=[CH:11][N:10]=[CH:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12870394HCID 12870394, compound

Product 1

HCID 57421209HCID 57421209, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

1.54 g of 2-imidazol-1-yl-2-methyl-propionic acid ethyl ester (73828-88-3) are dissolved in 20 ml of methanol. 20 ml of a 3M NaOH are added and the mixture is stirred for 16 hours at 60° C. The reaction mixture is then neutralised with 1M HCl and concentrated by evaporation. The title compound is identified from the residue by means of flash chromatography (SiO2 60F) based on its Rf value.

Workup

  1. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-69290d1bcc9e4261b1814a0d73068d87
Source dataset
uspto-grants-2010_05
Patent number
US07718675B2

Reaction notes

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