Pyridinium chloride → HCID 13051489, compound

HRID 223776Notes

Reaction equation

HRID 223776 reaction equation
Cl.N1C=CC=CC=1.C[O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[C:17](=[O:30])[NH:18][CH:19]=[C:20]3[C:25]=2[NH:24][C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[S:21]3)=[CH:12][CH:11]=1>O>[OH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[C:17](=[O:30])[NH:18][CH:19]=[C:20]3[C:25]=2[NH:24][C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[S:21]3)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 13051486HCID 13051486, compound

Product 1

HCID 13051489HCID 13051489, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 10 parts pyridine hydrochloride heated to 170° under a stream of nitrogen is added 0.5 parts of 4-(4-methoxyphenyl)-5H-pyrido[3,4-b][1,4]benzothiazine-3(2H)-one in one portion. The reaction mixture is refluxed for 45 minutes, cooled, water is added and the solid which forms is collected and dried to yield 4-(4-hydroxyphenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one, m.p. greater than 300°.

Workup

  1. temperatureThe reaction mixture is refluxed for 45 minutes
  2. temperaturecooled
  3. customthe solid which forms is collected
  4. customdried

Sources & evidence

ORD record
ord-8e9914adc90b4237add49160bfda9f89
Source dataset
uspto-grants-1982_10
Patent number
US04356302

Reaction notes

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