Pyridinium chloride → HCID 13051489, compound

Participants

Reaction Steps

To 10 parts pyridine hydrochloride heated to 170° under a stream of nitrogen is added 0.5 parts of 4-(4-methoxyphenyl)-5H-pyrido[3,4-b][1,4]benzothiazine-3(2H)-one in one portion. The reaction mixture is refluxed for 45 minutes, cooled, water is added and the solid which forms is collected and dried to yield 4-(4-hydroxyphenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one, m.p. greater than 300°.

Provenance & Evidence