HRID2237934

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74852

1,1-Diethoxy-2-bromoethane

C6H13BrO2

HCID50851130

5-Bromo-3-fluoropyridin-2-amine

C5H4BrFN2

PRODUCTS

生成物

HCID22031933

6-Bromo-8-fluoroimidazo[1,2-a]pyridine

C7H4BrFN2

收率 89%

PROCEDURE

实验过程

Prepared from 5-bromo-3-fluoro-pyridin-2-ylamine (example C.29 step 3) (3.1 g, 15.7 mmol) and bromoacetaldehyde diethyl acetal (90%, 4.86 mL, 31.3 mmol) as described in example C.20 step 1. Obtained the title compound as a light brown solid (3.0 g, 89%). MS (ISP) 215.1 [(M+H)+], 217.1 [(M+2+H)+].