HCID 67458808, compound → HCID 67462825, compound

HRID 2238500Notes

Reaction equation

HRID 2238500 reaction equation
[CH3:1][C:2](=[CH2:17])[CH2:3][N:4]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:5]1[C:6]([O:8]C(C)(C)C)=[O:7]>ClCCl.FC(F)(F)C(O)=O>[CH3:17][C:2](=[CH2:1])[CH2:3][N:4]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:5]1[C:6]([OH:8])=[O:7]

Participants

4

Reactant 1

HCID 67458808HCID 67458808, compound

Product 1

HCID 67462825HCID 67462825, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1,1-dimethylethyl 1-(2-methyl-2-propen-1-yl)-5-oxoprolinate (0.099 g, 0.41 mmol) was dissolved in a mixture of dichloromethane (2 ml) and trifluoroacetic acid (2 ml) and stirred overnight at room temperature. The solvent was evaporated (azeotroping with toluene to remove traces of trifluoroacetic acid) to give crude 1-(2-methyl-2-propen-1-yl)-5-oxoproline as a brown oil which was used without further purification.

Workup

  1. customThe solvent was evaporated
  2. custom(azeotroping with toluene to remove traces of trifluoroacetic acid)

Sources & evidence

ORD record
ord-36378cd6ada443dc9031b79b334341a3
Source dataset
uspto-grants-2010_05
Patent number
US07718693B2

Reaction notes

Loading…