反应详情

A mixture of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one (1.0 g, 0.687 mmol) and ethanol (small amount) was concentrated under reduced pressure, followed by adding ethyl acetate (small amount) to the residue before further concentration under reduced pressure. A 10% (v/v) H2SO4/ethyl acetate solution (0.439 mL, 0.824 mmol) was added to an ethyl acetate (15 mL) suspension containing the resultant residue, which was then stirred at room temperature for 4 days. The precipitated solid was collected by filtration, washed with ethyl acetate (small amount), and then dried under reduced pressure to provide 475 mg of the title compound as white crystals.

1. concentrationwas concentrated under reduced pressure
2. additionby adding ethyl acetate (small amount) to the residue
3. concentrationbefore further concentration under reduced pressure
4. filtrationThe precipitated solid was collected by filtration
5. washwashed with ethyl acetate (small amount)
6. customdried under reduced pressure