反应详情

A mixture of concentrated sulfuric acid (60 μL, 1.08 mmol) and tetrahydrofuran (5 mL) was added under cooling with ice to a mixture of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one (200 mg, 0.138 mmol) and tetrahydrofuran (20 mL), which was then stirred under cooling with ice for one hour. The precipitated solid was collected by filtration, washed with ethyl acetate (small amount), and then dried under reduced pressure to provide 212 mg of the title compound as white crystals.

1. additionwas added
2. temperatureunder cooling with ice for one hour
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with ethyl acetate (small amount)
5. customdried under reduced pressure