1-Methylpiperazine → HCID 59303884, compound

HRID 2238592Notes

Reaction equation

HRID 2238592 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([O:11][C:12]2[C:20]3[N:19]=[C:18]([CH3:21])[N:17]([CH3:22])[C:16]=3[CH:15]=[C:14]([C:23]([OH:25])=O)[CH:13]=2)[CH2:3][CH2:2]1.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([O:11][C:12]2[C:20]3[N:19]=[C:18]([CH3:21])[N:17]([CH3:22])[C:16]=3[CH:15]=[C:14]([C:23]([N:30]3[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]3)=[O:25])[CH:13]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 686891664-(3,4-Dihydro-2H-chromen-4-yloxy)-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid

Product 1

HCID 59303884HCID 59303884, compoundYield 34%

Procedure

The title compound was prepared as a white solid in 34% yield (30 mg) from 4-(3,4-dihydro-2H-chromen-4-yloxy)-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid (70 mg, 0.21 mmol, STEP 2 of Example 11) and 1-methylpiperazine (41 mg, 0.42 mmol) by the same manner in STEP 3 of Example 11:

Sources & evidence

ORD record
ord-1668bdad362f421daf88d490ef8cb085
Source dataset
uspto-grants-2010_05
Patent number
US07718809B2

Reaction notes

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