HCID 59006385, compound → 3-Ethylpyridin-2-amine

HRID 2238667Notes

Reaction equation

HRID 2238667 reaction equation
[N+:1]([C:4]1[C:9]([CH:10]=[CH2:11])=[CH:8][CH:7]=[CH:6][N:5]=1)([O-])=O.[H][H]>C(O)C.[C].[Pd]>[CH2:10]([C:9]1[C:4]([NH2:1])=[N:5][CH:6]=[CH:7][CH:8]=1)[CH3:11]

Participants

5

Reactant 2

HCID 59006385HCID 59006385, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 110516363-Ethylpyridin-2-amineYield 83.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

130 mg of the 2-nitro-vinylpyridine [120-1] was dissolved in 5 mL of ethanol, 65 mg of 10% palladiumcarbon catalyst was added thereto, and stirred overnight at room temperature in a hydrogen atmosphere. The insolubles were filtered through celite, the filtrate was concentrated under reduced pressure, and 88.7 mg of 3-ethylpyridin-2-amine [120-2] was obtained as a yellow oily product.

Workup

  1. filtrationThe insolubles were filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a5a9bf2141d04bada4568a212eaaf274
Source dataset
uspto-grants-2010_05
Patent number
US07718801B2

Reaction notes

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